PDF version of this entire document

... and Christopher J. Taylor

[DRAFT Placeholder] Manuscript received January 20, 2006 for the TMI special issue on validation; revised March 1, 2006. The work of R. S. Schestowitz was supported by the EPSRC. The work of W. R. Crum was also supported by the EPSRC and fell under the IBIM project 'umbrella'. Asterisk indicates corresponding author

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

...

*R. S. Schestowitz is with the Division of Imaging Science and Biomedical Engineering, Stopford Building, Oxford Road, University of Manchester, M13 9PT Manchester, United Kingdom.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

...

W. R. Crum is with the Centre for Medical Image Computing, Department of Computer Science, Gower Street, University College London, London WC1E 6BT, United Kingdom. All other authors are with the Division of Imaging Science and Biomedical Engineering, University of Manchester, M13 9PT Manchester, United Kingdom.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

...

Publisher Item Identifier [placeholder].

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

... brains

The age matched normals in a dementia study generously provided by X (anonymised).

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.