Results of the proposed measures for increasing registration perturbation are shown in Fig. 11 and Fig. 12. Note that Generalisationand and Specificity plotted for different shuffle neighbourhood radius are in error form, i.e. they increase with decreasing performance. Also shown in Fig. 10 are results from the Tanimoto overlap-based measure, which computes the measure that is based on ground truth. All metrics are generally well-behaved and show a monotonic decrease in registration performance. Such results directly validate the model-based metrics, which are shown be in agreement with the ground truth embodied in the region overlap based measure.
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