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... and Christopher J. Taylor

[DRAFT Placeholder] Manuscript received February .., 2006 for the TMI special issue on validation

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This research was supported by the MIAS IRC project, EPSRC grant No. GR/N14248/01, UK Medical Research Council Grant No. D2025/31 (``From Medical Images and Signals to Clinical Information''), and also by the IBIM project, EPSRC grant No. GR/S82503/01 (``Integrated Brain Image Modelling'')

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W. R. Crum is with the Centre for Medical Image Computing, Department of Computer Science, Gower Street, University College London, London WC1E 6BT, United Kingdom. All other authors are with the Division of Imaging Science and Biomedical Engineering, University of Manchester, M13 9PT Manchester, United Kingdom.

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... brains.

The age-matched normals in a dementia study generously provided by Neil Thacker and Paul Bromiley, Manchester.

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