The Two Approaches
Overlap-based:
Exploits a generalisation of Tanimoto's spatial overlap measure [1] . We start with a manual mark-up of each image, providing an anatomical/tissue label for each voxel, and measure the overlap of corresponding labels following registration.
Model-based:
We automatically build an apperance model from the correspondences identified by a registration. We then synthesise images from the model and perform a cross-imageset comparison to assess model/registration quality.
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