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Overlap-based Assessment

The approach utilizes a measure of overlap between ground-truth anatomical labels. It exploits a generalisation of Tanimoto's spatial overlap measure [1] . We start with a manual mark-up of each image, providing an anatomical/tissue label for each voxel, and measure the overlap of corresponding labels following registration.

• Each label is represented using a binary image
• Becomes fuzzy after interpolation
• Combined in a generalised overlap score
  1. implicitly volume weighted
  2. inverse label volume
  3. inverse label volume squared
  4. label complexity

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