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Acknowledgements:

• Many thanks to David Kennedy of the Centre for Morphometric Analysis at MGH for segmented brain data.
• The work was supported by:
  • EPSRC/MRC-funded Medical Image and Signal IRC (GR/N14248/01)
  • Integrated Brain Image Modelling (EPSRC GR/S82503/01)
  • Modelling, Understanding and Predicting Structural Brain Change (EPSRC GR/S48844/01)