**OVERLAP-BASED ASSESSMENT**

The approach utilizes a measure of overlap between ground-truth anatomical labels. It exploits a generalisation of Tanimoto's spatial overlap measure [1] . We start with a manual mark-up of each image, providing an anatomical/tissue label for each voxel, and measure the overlap of corresponding labels following registration.

- Labels are represented using binary images
- Becomes fuzzy after interpolation
- Combined in a generalised overlap score
- implicitly volume weighted
- inverse label volume
- inverse label volume squared
- label complexity

Roy Schestowitz 2006-04-22