The search for an assessment method that uses the image data alone is motivated by numerous factors:
The need for ground-truth-free methods of evaluation has been recognised in other areas. The STAPLE algorithm [] from Warfield et al. addresses the problem of evaluating complete segmentations of an object. The method uses an E-M algorithm to estimate the most likely ground truth, given the set of segmentations.
Roy Schestowitz 2010-04-05