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[News] Linux Inspires the Pharmaceutical Industry

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TDI kernel web site

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| There is an urgent need for identifying new targets for drug discovery. This 
| urgency is even more relevant for infectious diseases affecting third-world 
| countries, which have been historically neglected by the pharmaceutical 
| industry. For example, only ~10% of the R&D resources have been spent on 
| illnesses that represent the 90% of the total disease burden in the world 
| (Munos 2006), which translates in that just ~1% of newly developed drugs are 
| for tropical diseases (Maurer et al. 2004).      
| At the beginning of the 90s, an initial Linux kernel conceived and created by 
| Linus Torvalds paved the way for a wealth of open and free software programs 
| and operating systems. Here we introduce what we believe can be regarded as 
| an initial kernel for drug discovery with the hope that it will sparkle new 
| ways for developing drugs against organisms that cause tropical diseases. The 
| TDI kernel (v1.0) includes 297 potential drug targets against the 10 selected 
| genomes and is freely and publicly accessible in a World Wide Web server, 
| which was developed with Web2.0 tools for easy dissemination of the deposited 
| data.        



Academic Astroturfing for Medical Profits

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| JAMA has a rather scathing editorial condemning what is apparently the 
| practice of ghostwriting and appending known specialists names as lead 
| authors in studies that are then used to promote pharmaceuticals and medical 
| devices.   


Open-source model for drug discovery?

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| Significant public funding along with the ability for private enterprise to 
| benefit from the open source approach will result in a strong public-private 
| partnership and ensure success of the open source approach.  


Open source drug discovery

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| The idea, taking off from successful open source models such as the human 
| genome sequencing initiative, is very simple. All the relevant data and 
| accumulated intelligence on a particular disease, tuberculosis to begin with, 
| would be hosted online.    


'Open source' urged for TB drug design effort

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| One of India's top genetics researchers has called for a global, 
| collaborative effort to design a new tuberculosis (TB) drug using an 'open 
| source' approach.  


Open Source Pharmaceuticals - New Business Model

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| Software is not the only field affected by open source; many fields of study 
| and social and political views have been affected by the growth of the 
| concept of open source. Advocates in one field will often support the 
| expansion of open source in other fields, including Linus Torvalds who is 
| quoted as saying, "the future is open source everything."    


Open source synthetic biology

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| Not everyone within synthetic biology takes the open-source approach, Andrew 
| Hessel, an iGEM consultant who recruits teams from Canadian universities, 
| told me, but the driving force behind it is iGEM and MIT (Rettberg works with 
| renowned hacker-turned-synthetic biologist Tom Knight). Hessel likened the 
| atmosphere to the time when computers were first becoming cheap enough to be 
| affordable by anyone who wanted one, and young, bright kids began to play 
| around with code.       


Biology Goes Open Source

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| Some of the world's biggest drug companies are finding that
| their genetic research is worth more to them if they give it away.


Pharmac publishes directly with open source

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| The team used Python, libxml/libxslt and TeX, running on Debian GNU/Linux, 
| and the open document standards TeX, XML, MathML, XHTML, and Xlink, says 
| Geering.   


Red Hat scores Swedish pharmacy contract

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| Apoteket, the pharmacy network, will convert to Red Hat Enterprise Linux 
| running on Intel hardware, Red Hat said. Financial terms of the deal were not 
| disclosed.  


Open Source Research -- the Power of Us

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| Open source methods have delivered tangible benefits in the computer
| science community. We describe here efforts to extend these principles
| to science generally, and in particular biomedical research. Open
| source research holds great promise for solving complex problems in
| areas where profit-driven research is seen to have failed. We
| illustrate this with a specific problem in organic chemistry that
| we think will be solved substantially faster with an open
| source approach.


Our Biotech Future [is Open Source]

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| Open Source biology could be a powerful tool, giving us access to 
| cheap and abundant solar energy.


Open-Source Drug Safety?

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| More than a million Americans take Avandia every year; the risk
| Glaxo had found would mean thousands of extra heart attacks. But
| the company argued that the risk only occurred in patients who
| already had serious heart problems, and that it didn't show up
| in long-term clinical trials. The FDA made no decision, and no 
| public statement.
| [...]
| It's an open source approach to drug safety.


Open Source Pharmaceuticals - New Business Model 

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| "Open source" as applied to culture defines a culture in which
| intellectual property is made generally available. Participants
| in such a culture are able to improve and modify those products
| and redistribute them back into the community.


Thailand fed up with high drug prices - minister

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| "We have thought about this for more than five years. It's long enough,"
| said Mongkol na Songkhla, who is leading one of the biggest challenges to
| Big Pharma's patent rights in years. 

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