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When a sensible registration algorithm is available to be used with brain data, it can then be compared to other methods developed within the IRC. Comparative tests are performed using a regular, annotated and standardised data. Software of Crum et al. (confer the paper to appear in MICCAI 2004) is able to carry out such comparisons. It relies on the database from Boston which comprises 8 brain volumes with ground-truth landmarks (annotated by professional radiologists). Validation [] of results with respect to other existing and to-be-established inter-operable software can be considered as well.