Monday, November 7th, 2022, 5:54 am
Research Into Lack of Correlation Between COVID-19 Infection and Myocarditis
Filed under: Covid infection did not increase incidence of post-covid myocarditis or pericarditis.
The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients-A Large Population-Based Study
https://pubmed.ncbi.nlm.nih.gov/35456309/
https://www.mdpi.com/journal/jcm
Myocarditis and pericarditis, post-acute cardiac sequelae of COVID-19 infection,
arising from adaptive immune responses.
? incidence
Retrospective cohort study
Study group, had infection
N = 196,992 adults after COVID-19 infection
(Clalit Health Services)
March 2020 to January 2021
Inpatient myocarditis and pericarditis diagnoses,
from day 10 after positive PCR
Israeli vaccination program initiated on 20 December 2020
Follow-up was censored on 28 February 2021
Control cohort, never infected
N = 590,976 adults,
with at least one negative PCR and no positive PCR
(age- and sex-matched)
Calculated backward from 15 December 2020
Results
Post-COVID-19 group
Nine post-COVID-19 patients developed myocarditis (0.0046%)
Eleven diagnosed with pericarditis (0.0056%)
Control group, never covid infected
27 developed myocarditis (0.0046%) P = 1
52 developed pericarditis (0.0088%) P = 0.17
Adjusted hazard ratio [aHR]
Myocarditis, male (aHR 4.42) regardless of previous COVID-19 infection
Pericarditis, (aHR 1.93)
Peripheral vascular disease, (aHR 4.20)
Follow up
Median, 4.1 months
Covid cohort, 700,040 person-months
Non covid cohort, 2,100,077 person-months
Conclusions
Post COVID-19 infection was not associated with myocarditis (aHR 1.08)
Post COVID-19 infection was not associated with pericarditis (aHR 0.53)
We did not observe an increased incidence of neither pericarditis nor myocarditis in adult patients recovering from COVID-19 infection.
Our data suggest that there is no increase in the incidence of myocarditis and pericarditis in COVID-19 recovered patients,
compared to uninfected matched controls.
