Sunday, December 4th, 2022, 10:36 pm
New Paper: Autopsy-based Histopathological Characterization of Myocarditis After Anti-SARS-CoV-2-Vaccination
Filed under: Description:
Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination
link.springer.com/article/10.1007/s00392-022-02129…
Likelihood assessment of vaccine-induced
(epi-)myocarditisCausality or correlation?
Presence of myocarditis with temporal association to vaccination event
AND
Integration of histological phenotype, clinical presentation, and laboratory findings indicate no alternative differential diagnosis
Abstract infographic
Cases of myocarditis
Have been diagnosed clinically,
by laboratory tests,
imaging
(in the context of mRNA-based anti-SARS-CoV-2 vaccination)
Autopsy-based description
We describe,
Cardiac autopsy findings and common characteristics of myocarditis,
with vaccine-induced myocardial inflammation representing the likely or possible cause of death.
Our findings establish the histological phenotype of lethal vaccination-associated myocarditis.
Standardized autopsies
Performed on 25 persons
25 bodies found unexpectedly dead at home,
within 20 days following SARS-CoV-2 vaccination
Histology
Patchy, focal, interstitial myocardial T-lymphocytic and macrophage
infiltration,predominantly of the CD4 positive sub- set, (T Helper cells)
associated with mild myocyte damage.
Autopsy findings indicated
Death due to acute arrhythmogenic cardiac failure.
Thus
Myocarditis can be a potentially lethal complication following mRNA-based anti-SARS-CoV-2 vaccination.
Our findings may aid in adequately diagnosing unclear cases after vaccination,
and in establishing a timely diagnosis in vivo, thus,
providing the framework for adequate monitoring and early treatment of severe clinical cases.
