Just published: Chinese vaccine comparisons

Description:

Chinese and Western vaccines compared

https://www.bbc.co.uk/news/world-asia-china-63855508

Big changes, all of a sudden

Live with the virus

Vice-premier, Sun Chunlan

China entering a new situation

Virus ability to cause disease weakening

Lifting most severe Covid policies

End of quarantine camps

People can isolate at home

No more family separations

Close contacts not taken to camps

Strict ban on blocking fire exits

No need to show tests for venues

Less rules on internal travel

Lateral flow tests to replace PCR tests in most areas

Lockdowns continue in smaller more targeted areas

Foreign travel soon

Cases, 30,000 +

Now

Everyone will be exposed

Will the medical system will be overwhelmed?

National Health Commission

All localities, focus on improving the vaccination rate of people aged 60-79,

accelerating the vaccination rate of people aged 80 and above,

and making special arrangements

Prof Ivan Hung, Hong Kong University

The main way for China to exit Covid with the least damage is via vaccination and three doses of vaccination is a must

Hopefully before Chinese New Year (January 22) Rabbit

Sinopharm

Strategic Advisory Group of Experts on Immunization (SAGE)

https://www.who.int/news-room/feature-stories/detail/the-sinopharm-covid-19-vaccine-what-you-need-to-know

The vaccine is safe and effective for all individuals aged 18 and above.

Individuals may choose to delay vaccination for 3 months following the infection.

An inactivated vaccine with adjuvant

(that is routinely used in many other vaccines)

with a documented good safety profile, including in pregnant women.

Symptomatic SARS-CoV-2 infection and efficacy against hospitalization 79%

Does it prevent infection and transmission?

No substantive data

Does it work against new variants of SARS-
CoV-2 virus?

SAGE currently recommends using this vaccine

Not yet been evaluated in the context of circulation of widespread variants of concern.

How does this vaccine compare to other vaccines already in use?

We cannot compare the vaccines head-to-head,

(different approaches taken in designing the respective studies)

but overall, all of the vaccines that have achieved WHO Emergency Use Listing,

are highly effective in preventing severe disease and hospitalization due to COVID-19.

Comparison with Western vaccines

Pfizer original paper

https://www.nejm.org/doi/full/10.1056/NEJMoa2034577

https://www.nejm.org/doi/suppl/10.1056/NEJMoa2034577/suppl_file/nejmoa2034577_appendix.pdf

BNT162b2 was 95% effective in preventing Covid-19

Later analysis from

Efficacy and effectiveness of covid-19 vaccine – absolute vs. relative risk reduction

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115787/

AAR, Pfizer, during the trial period,

0.84%

AAR

https://patient.info/news-and-features/calculating-absolute-risk-and-relative-risk

Absolute risk of a disease is your risk of developing the disease over a time period.

Five to six-months update, AAR

BNT162b2 3.7%

mRNA1273 (Moderna-NIH) 4.9%

Last week: In Week 46 (ONS Released the Full Provisional Figures Yesterday), Adults Aged 15-44 Saw 35.5% Rise in Deaths (2022 Compared to 2019)

Latest numbers here.

In week 47 of 2019, 283 adults aged 15-44 died in England and Wales.

In week 47 of 2022, 359 adults aged 15-44 died in England and Wales.

359 – 283 = 76 or 27% higher in 2022 than in 2019.

What’s the cause if it’s not COVID-19 and not “Long COVID”? One can guess and Germany studies the matter.

The following figures came out this morning (England and Wales total deaths per week):

England and Wales deaths per week, now with week 47 (it’s higher this year than it was last year)

Source: ONS

Here is how that compared to pre-COVID-19 years:

Deaths above normal in 2022, based on complete statistics, not a random sample. Values above 0 mean deaths higher than pre-COVID-19 for a given week. Counting the deaths since week 22, we have 37,000 more deaths in England and Wales this year than average prior to the pandemic. That’s a LOT of people.

Data: As ODF

Description:

Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination

link.springer.com/article/10.1007/s00392-022-02129…

Likelihood assessment of vaccine-induced
(epi-)myocarditis

Causality or correlation?

Presence of myocarditis with temporal association to vaccination event

AND

Integration of histological phenotype, clinical presentation, and laboratory findings indicate no alternative differential diagnosis

Abstract infographic

Cases of myocarditis

Have been diagnosed clinically,

by laboratory tests,

imaging

(in the context of mRNA-based anti-SARS-CoV-2 vaccination)

Autopsy-based description

We describe,

Cardiac autopsy findings and common characteristics of myocarditis,

with vaccine-induced myocardial inflammation representing the likely or possible cause of death.

Our findings establish the histological phenotype of lethal vaccination-associated myocarditis.

Standardized autopsies

Performed on 25 persons

25 bodies found unexpectedly dead at home,

within 20 days following SARS-CoV-2 vaccination

Histology

Patchy, focal, interstitial myocardial T-lymphocytic and macrophage
infiltration,

predominantly of the CD4 positive sub- set, (T Helper cells)

associated with mild myocyte damage.

Autopsy findings indicated

Death due to acute arrhythmogenic cardiac failure.

Thus

Myocarditis can be a potentially lethal complication following mRNA-based anti-SARS-CoV-2 vaccination.

Our findings may aid in adequately diagnosing unclear cases after vaccination,

and in establishing a timely diagnosis in vivo, thus,

providing the framework for adequate monitoring and early treatment of severe clinical cases.

The official numbers.

The underlying figures:

Deaths for week 46. Ages 15-44 in 2022:

Same for 2019:

That’s 354 compared to 271 before pandemic.

The latest official slant is that it’s not COVID-19. So what is it then killing so many people?

Today’s statement from ONS:

The number of deaths involving COVID-19 in the UK continued to fall from 583 to 471 in the latest week (ending 18 November 2022).

There were a total of 13,236 deaths registered in the UK in the latest week, which was 7.7% above the five-year average.

Deaths involving COVID-19 accounted for 3.6% of all deaths in the UK in the latest week; this is a fall from 4.4% in the previous week.

Of all deaths involving COVID-19 registered in the UK in the latest week 401 were registered in England, 21 in Wales, 40 in Scotland and 8 in Northern Ireland.

In England, the number of deaths involving COVID-19 fell among those aged 25 to 44 years, and 65 years and over. Deaths remained similar among those aged 24 years and under, and those aged 45 to 64 years.

There were no deaths involving COVID-19 among those aged 24 years and under. COVID-19 deaths were low among those aged 25 to 44 years.

Deaths involving COVID-19 rose in Yorkshire and The Humber, fell in the North East, the North West, the East Midlands, the East of England, London, the South East and the South West, and remained stable in the West Midlands.

Our data are based on deaths registered in the UK and include all deaths where “novel coronavirus (COVID-19)” was mentioned on the death certificate. More information for England and Wales is available in our weekly Death registrations and occurrences by local authority/health board dataset.

“There were a total of 13,236 deaths registered in the UK in the latest week,” they say, “which was 7.7% above the five-year average” and it is far higher if one doesn’t count 2021 and 2020, two pandemic years. So many people are dying. Why? They need to investigate the root cause.

Dr. John Campbell has already responded to it:

ONS had an update earlier today:

The total numbers of deaths remain conspicuously big:

Increased deaths in England and Wales (blue is the total, red is the 2022 increase over pre-COVID-19 levels)

Data: Deaths by week (weeks 1-46) average (ODF)